Perioperative medicine & outcomes
The omission of routine preoperative midazolam prescription is associated with increased preoperative sympathetic activation but not mortality: a propensity score matched, before-and-after study
Main findingResult — go to the resultOdds ratio 0.91 95% CI 0.60–1.38Authors' conclusion
Midazolam prescription was not associated with increased mortality in a large cohort of surgical patients but with a lower pre-induction blood pressure and heart rate, suggesting a potential reduction in cardiovascular stress.
Study context
- Population
- Adults undergoing GA, university hospital in Germany, December 1, 2017 to November 31, 2019propensity-matched
- Participants
- 7,421 vs 7,421
- Exposure
- Midazolam premedication vs no midazolam
- Midazolamn = 7,421
- No midazolamn = 7,421reference
- Outcome
- In-hospital mortality after general surgery
Methodological detailsbefore-and-after, propensity score-matched, single-centre
- Before-and-after
- Propensity score-matched
- Single-centre
Main finding
As reported in the abstract
Odds ratio
0.91
95% CI 0.60–1.38
P = 0.662
Midazolam vs No midazolam
OR 0.91 (95% CI 0.60–1.38); P = 0.662
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Estimated average treatment effect (mmHg) (95% CI) |
|---|---|
| Pre-induction SBPSE 0.41 | - 5.33 (- 6.13 to - 4.52) |
Original publication
The omission of routine preoperative midazolam prescription is associated with increased preoperative sympathetic activation but not mortality: a propensity score matched, before-and-after study. Perioper Med (Lond). Published 30 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →