Respiratory failure & ventilation
Personalized positive-end expiratory pressure using electrical impedance tomography in Acute Respiratory Distress Syndrome (ARDS) patients: a systematic review and meta-analysis
Authors' conclusion
EIT-guided PEEP titration improves oxygenation and respiratory system compliance in patients with ARDS, supporting its role as a physiology-based strategy for ventilatory personalization.
Study context
- Population
- Adults with ARDS
- Participants
- 356 adults · 9 studies
- Comparison
- Electrical Impedance Tomography (EIT)-guided vs conventional positive end-expiratory pressure (PEEP) titration
- Outcome
- PaO2/FiO2 ratio and respiratory system compliance (Crs)
Methodological detailsrandom-effects meta-analysis, PRISMA 2020, MOOSE, GRADE
- Random-effects meta-analysis
- PRISMA 2020
- MOOSE
- GRADE
Pooled result
As reported in the abstract
MD
+ 60.81
95% CI 30.37–91.25
PaO2/FiO2 ratio; low heterogeneity
MD
+ 6.81 mL/cm H2O
95% CI 3.73–9.89
Respiratory system compliance
Further pooled results
Driving pressure (ΔP)
| MD (cm H2O) (95% CI) | ||
|---|---|---|
| Between groups | −0.78 (−1.63 to 0.07) | |
| −2−101Difference, cm H2O (linear scale) |
Mechanical power (MP)
| MD (J/min) (95% CI) | ||
|---|---|---|
| Across groupsNon-significant difference | −0.76 (−2.30 to 0.78) | |
| −3−2−101Difference, J/min (linear scale) |
Mortality
| Risk ratio (95% CI) | ||
|---|---|---|
| Between groups | 0.88 (0.45–1.72) | |
| 0.512Risk ratio (log scale) |
Original publication
Personalized positive-end expiratory pressure using electrical impedance tomography in ARDS patients: a systematic review and meta-analysis. Ann Intensive Care. Published 16 March 2026. doi:10.
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