Phenotype- and species-specific skin proteomic signatures for incision-induced pain in humans and mice
Authors' conclusion
Proteome profiling of human skin after incision revealed protein-protein interactions correlated with pain and hyperalgesia, which may be of potential significance for preventing chronic post-surgical pain.
Study context
- Population
- Male human volunteers and male mice with standardised surgical incisions
- Participants
- 21 human volunteers
- Comparison
- High responders vs low responders; humans vs mice
- High respondersn = 7
- Low respondersn = 12reference
- Outcome
- Skin protein signature changes in humans and phenotype-specific protein-protein interaction analysis
- Follow-up
- 24 h after incision
Methodological detailstranslational human and mouse incision model, mass spectrometry-based proteomics
- Translational human and mouse incision model
- Mass spectrometry-based proteomics
Main finding
As reported in the abstract
Skin protein regulation and PPI
Regulated proteins in human skin
119 of 1569
Secondary outcomes
Interspecies comparison (mice) · 24 h after incision
- Regulated proteins in mouse skin
- 435/1871
- Limited overlap between species in proteome dynamics and PPI
Validation in human skin by immunofluorescence
- Expression of high priority candidates confirmed in human skin biopsies
Original publication
Phenotype- and species-specific skin proteomic signatures for incision-induced pain in humans and mice. Br J Anaesth. Published 5 January 2023. doi:10.
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