ICU sedation, delirium & recovery

Physical impairment as the dominant component of new-onset post-intensive care syndrome following in-hospital resuscitation

ResuscitationPublished Nationwide population-based cohort study

Authors' conclusion

New-onset PICS, driven by physical decline, affects one in six IHCA survivors surviving the first year.

Study context

Population
In-hospital cardiac arrest (IHCA) hospital survivors, South Korean National Health Insurance Service database (2013–2023)
Participants
43,331 hospital survivors
Outcome
Cumulative incidence of new-onset PICS (ICD-10 coded diagnoses; healthcare utilization-based incidence)
Follow-up
12 months
Methodological detailsadministrative claims database, ICD-10 coded diagnoses
  • Administrative claims database
  • ICD-10 coded diagnoses

Main finding

As reported in the abstract

Cumulative incidence of new-onset PICS

12-month cumulative incidence of new-onset post-intensive care syndrome (PICS)

6.7%

95% CI 6.5–6.9%

Observational data: associations, not effects.

Further findings

Incidence of new-onset PICS in stable one-year survivors (sensitivity analysis, n = 11,862)

Incidence of new-onset PICS
15.9% (95% CI 15.3-16.6%)
Physical impairment domain
15.0%
Cognitive domain
0.5%
Psychiatric domain
0.8%
  • Sensitivity analysis

Predictors of PICS

ECMO support, OR (P < 0.001)
1.44
Odds of PICS diagnosis in 2022, OR
2.19
Odds of PICS diagnosis in 2023, OR
2.12
Increased length of hospitalization a robust predictor
  • Odds of PICS diagnosis significantly escalated from 2021 onwards

Original publication

Physical impairment as the dominant component of new-onset post-intensive care syndrome following in-hospital resuscitation. Resuscitation. Published 10 April 2026. doi:10.1016/j.resuscitation.2026.111085

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