Respiratory failure & ventilation
Physiological comparison of noninvasive ventilation and high-flow nasal oxygen on inspiratory efforts and tidal volumes after extubation: a randomized crossover trial
Authors' conclusion
In patients at high-risk of extubation failure, prophylactic NIV significantly decreased inspiratory efforts with increased tidal volumes compared to HFNO.
Study context
- Population
- Patients at high risk of extubation failure (> 65 years old or underlying cardiac or respiratory disease) after planned extubationretained in analysis
- Participants
- 20 patients
- Comparison
- Prophylactic non-invasive ventilation (NIV) vs high-flow nasal oxygen (HFNO) after planned extubation
- Primary endpoint
- Inspiratory efforts (simplified esophageal pressure-time-product per minute, sPTPes, cmH2O s/min)
Methodological detailsprospective physiological study
- Prospective physiological study
Primary result
As reported in the abstract
Inspiratory efforts (sPTPes)
P < 0.001
Further findings
Tidal volume (electrical impedance tomography) · larger with NIV
P = 0.005
Dorsal region ventilation
- Non-significant increase under NIV vs HFNO
Original publication
Physiological comparison of noninvasive ventilation and high-flow nasal oxygen on inspiratory efforts and tidal volumes after extubation: a randomized crossover trial. Crit Care. Published 8 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →