Pediatric anesthesia & critical care
Pilot Assessment of Platelet Thrombus Area and Contractile Force in Pediatric Congenital Heart Surgery Patients Using a Microfluidic Device
Authors' conclusion
In pediatric CHD patients, microfluidic testing demonstrated that platelet thrombus area increased slightly after CPB, while platelet contractile force did not change.
Study context
- Population
- Pediatric congenital heart disease (CHD) patients ≤8 years with expected cardiopulmonary bypass (CPB) time >30 minutes undergoing congenital heart surgery
- Participants
- 20 patients
- Exposure
- Post-CPB and post-CPB + recombinant von Willebrand factor (rVWF) vs pre-CPB samples
- Outcome
- Maximum thrombus area and maximum platelet contractile force
Methodological detailssingle academic medical centre, pilot
- Single academic medical centre
- Pilot
Main finding
As reported in the abstract
Baseline
0.06
interval 0.05–0.07
- Post-CPB vs Baseline · larger post-CPB vs pre-CPB
- estimated coefficient (maximum thrombus area) 0.04; P = 0.002
- Post-CPB + rVWF vs Baseline · larger post-CPB + rVWF vs pre-CPB
- estimated coefficient (maximum thrombus area) 0.09; P < 0.001
- Post-CPB + rVWF vs Post-CPB
- estimated coefficient (maximum thrombus area) 0.04; P = 0.001
- Post-CPB + rVWF vs Baseline · force higher post-CPB + rVWF vs pre-CPB
- estimated coefficient (maximum force) 173.32; P = 0.044
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Pilot Assessment of Platelet Thrombus Area and Contractile Force in Pediatric Congenital Heart Surgery Patients Using a Microfluidic Device. J Cardiothorac Vasc Anesth. Published 17 June 2024. doi:10.
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