ICU sedation, delirium & recovery
Plasma antioxidant capacity as a predictor of mortality in critically ill patients
Main finding · Association of FRAP with 90-day mortalityResult — go to the resultHazard ratio 4.69Authors' conclusion
Elevated plasma Ferric Reducing Antioxidant Power levels in postoperative critically ill patients are associated with shock severity, endothelial injury and increased mortality, particularly in those with septic shock.
Study context
- Population
- Critically ill postoperative patients admitted to ICUs at three Spanish hospitals (2021–2026)
- Participants
- 464 patients · 3 Spanish hospitals
- Exposure
- Plasma Ferric Reducing Antioxidant Power (FRAP) levels and 90-day mortality
- Outcome
- 90-day mortality
- Follow-up
- 90 days
Methodological detailsmulticentre
- Multicentre
Main finding
Association of FRAP with 90-day mortality
Hazard ratio
4.69
P < 0.05
As reported in the abstract
- FRAP discrimination for 90-day mortality, AUC
- 0.881 (95% CI 0.775-0.987)
Observational data: associations, not effects.
Further findings
FRAP levels by shock and survival status
- FRAP significantly higher in shock, particularly septic shock, and in non-survivors (p < 0.001)
FRAP and APACHE II
- FRAP positively correlated with APACHE II scores
- Slightly higher discriminative performance for FRAP vs APACHE II; combined FRAP-APACHE II models improved in precision-recall analyses
Endothelial damage
- Elevated FRAP associated with endothelial damage and with increased FRAP levels in HUVEC supernatants
Original publication
Plasma antioxidant capacity as a predictor of mortality in critically ill patients. Crit Care. Published 3 June 2026. doi:10.
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