Cardiac arrest & resuscitation
Plasma phosphorylated tau (p-tau231) and total tau (t-tau) as prognostic markers of neurological outcome after cardiac arrest - a multicentre study
Main finding · Neurological outcome (CPC), prognostic performanceResult — go to the resultAUC 0.95 95 % CI 0.93–0.98Authors' conclusion
Although p-tau231 showed moderate neurological prognostic ability, t-tau was a stronger predictor, particularly at 48 h, even after adjusting for clinical covariates.
Study context
- Population
- Cardiac arrest patients admitted to ICU
- Participants
- 425 patients
- Exposure
- Plasma p-tau231 vs t-tau for prognosis of neurological outcome
- Outcome
- Long-term neurological outcome (CPC)
Methodological detailsmulticentre, observational, p-tau231 retrospectively analysed at admission, 12 and 48 h
- Multicentre
- Observational
- p-tau231 retrospectively analysed at admission, 12 and 48 h
Main finding
As reported in the abstract
Neurological outcome (CPC), prognostic performance
AUC
0.95
95 % CI 0.93–0.98
P < 0.001
By group
p-tau231
- AUC on admission
- 0.69
- AUC at 12 h
- 0.72
- AUC at 48 h
- 0.71
T-tau
- AUC at 48 h, adjusted for covariates
- 0.95
- 95% CI
- 0.93-0.98
Clinical covariate reference model
- AUC
- 0.88
- 95% CI
- 0.84-0.93
AUC on admission
p-tau2310.69
T-tau— not stated in the abstract
Clinical covariate reference model— not stated in the abstract
AUC at 12 h
p-tau2310.72
T-tau— not stated in the abstract
Clinical covariate reference model— not stated in the abstract
AUC at 48 h
p-tau2310.71
T-tau— not stated in the abstract
Clinical covariate reference model— not stated in the abstract
AUC at 48 h, adjusted for covariates
p-tau231— not stated in the abstract
T-tau0.95
Clinical covariate reference model— not stated in the abstract
95% CI
p-tau231— not stated in the abstract
T-tau0.93-0.98
Clinical covariate reference model0.84-0.93
AUC
p-tau231— not stated in the abstract
T-tau— not stated in the abstract
Clinical covariate reference model0.88
- Increasing p-tau231 levels significantly associated with worse Cerebral Performance Category (CPC)
- P < 0.001
- Elevated t-tau significantly associated with worse outcome at all time points
- P < 0.001
Observational data: associations, not effects.
Original publication
Plasma phosphorylated tau (p-tau231) and total tau (t-tau) as prognostic markers of neurological outcome after cardiac arrest - a multicentre study. Resuscitation. Published 3 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →