Plasma Trough Concentrations of Beta‐Lactam Antibiotics in the Early Phase of Septic Shock
An erratum to this article was published (Acta Anaesthesiol Scand, Aug 2025 ↗)
Authors' conclusion
Our findings demonstrate considerable variability in antibiotic exposure during the initial 24 h of septic shock treatment
Study context
- Population
- Patients with septic shock (SEPSIS-3) receiving cefotaxime, piperacillin/tazobactam or meropenem, Swedish practice
- Participants
- 22 patients
- Outcome
- Plasma ß-LA concentrations; target 100% fT > MIC
- Follow-up
- First 24 h of treatment
Main finding
As reported in the abstract
Antibiotic exposure exceeding 100% fT > MIC
Patients achieving antibiotic exposure exceeding 100% fT > MIC
16
73%
Observational data: associations, not effects.
Further findings
Missed recommended additional dose between first and second doses
- Patients not receiving the recommended additional dose
- 4
- Of these, achieved 100% fT > MIC
- 2
- Of these, fT > MIC attained by the other two
- 66% and 33%
- Patients receiving the additional dose who did not achieve 100% fT > MIC
- 4
In-hospital mortality
- In-hospital mortality
- 7/22 (32%)
- No relationship between mortality and fT > MIC
Factors associated with achieving 100% fT > MIC
- Older age
- P = 0.045
- Illness severity (SAPS3)
- P = 0.025
Original publication
Plasma Trough Concentrations of Beta‐Lactam Antibiotics in the Early Phase of Septic Shock. Acta Anaesthesiol Scand. Published 2 May 2025. doi:10.
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