Respiratory failure & ventilation
Positive End-expiratory Pressure Is Associated With Apparent Increases in Single-beat Left-ventricular End-systolic Elastance: Implications of Stroke Volume Sensitivity
Authors' conclusion
Apparent increases in single-beat left-ventricular Ees during PEEP titration were consistent with substantial stroke volume-related mathematical sensitivity of the single-beat formulation.
Study context
- Population
- Adults undergoing elective noncardiac surgery under GA
- Participants
- 105 adults
- Exposure
- Graded positive end-expiratory pressure (PEEP) during controlled mechanical ventilation
- Outcome
- Change per 5 cmH2O increase in PEEP
Methodological detailssingle tertiary-care hospital, linear mixed-effects models
- Single tertiary-care hospital
- Linear mixed-effects models
Main finding
As reported in the abstract
Increase, mmHg/mL (95% CI)P value
Ees per 5 cmH2O PEEP increase
0.55(0.49–0.61)
P < 0.001Ea per 5 cmH2O PEEP increase
0.24(0.20–0.27)
P < 0.001Per 5 cmH2O PEEP increase, as printed
- Ea/Ees per 5 cmH2O PEEP increase
- decrease 0.04 (95% CI −0.05 to −0.03); P < 0.001
Observational data: associations, not effects.
Further findings
Stroke volume
| Change (mL) (95% CI) | P value | ||
|---|---|---|---|
| PEEP increaseDecrease · linear mixed-effects models | −9.1 (−9.9 to −8.4) | P < 0.001 | |
| −10−505Difference, mL (linear scale) |
Heart rate
- Heart rate remained unchanged
Ees (sensitivity analyses)
- Apparent Ees increase disappeared when assuming SV at PEEP 0 cmH2O
- Persisted when assuming baseline-estimated normalized ventricular elastance at arterial end-diastole or applying transmural pressure correction
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Positive End-expiratory Pressure Is Associated With Apparent Increases in Single-beat Left-ventricular End-systolic Elastance: Implications of Stroke Volume Sensitivity. J Cardiothorac Vasc Anesth. Published 14 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →