Perioperative medicine & outcomes
Positive End‐Expiratory Pressure, Tidal Volume, and Fraction of Inspired Oxygen During General Anaesthesia in High‐Risk Patients—A Randomised Clinical Feasibility Trial
Authors' conclusion
Adherence to interventions was acceptable, although below feasibility goals. Few postoperative complications were more frequent in patients receiving PEEP 8 and 10, and in patients receiving FiO2 of 80%.
Study context
- Population
- ASA 3–5 patients scheduled for major surgery under GA, 8 hospitals in Denmark
- Participants
- 483 participants · 8 hospitals
- Comparison
- Positive end-expiratory pressure (PEEP) 5, 8 or 10 cm H2O; tidal volume 6, 8 or 10 mL/kg; Fraction of inspired oxygen (FiO2) 30% or 80%
- Primary endpoint
- Feasibility of delivering the ventilatory interventions
Methodological detailsmulticentre, factorial, feasibility
- Multicentre
- Factorial
- Feasibility
Primary result
As reported in the abstract
Feasibility
- Feasibility goals not met, but clear separation within each intervention achieved
Secondary outcomes
- No differences between groups in most postoperative outcomes; outcomes did not differ between tidal volume interventions
Safety
| Outcome | OR (95% CI) | |
|---|---|---|
| Cardiac arrhythmiasPEEP 8 vs PEEP 5 | 9.32 (1.59–178) | |
| Cardiac arrhythmiasPEEP 10 vs PEEP 5 | 6.71 (1.00–134) | |
| PneumoniaFiO2 80% vs FiO2 30% | 4.04 (1.40–14.6) | |
| Emergence deliriumFiO2 80% vs FiO2 30% | 5.56 (1.94–20.4) | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Positive End‐Expiratory Pressure, Tidal Volume, and Fraction of Inspired Oxygen During General Anaesthesia in High‐Risk Patients—A Randomised Clinical Feasibility Trial. Acta Anaesthesiol Scand. Published 27 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →