Anaesthetic drugs & techniques
Blood Pressure Targets During General Anaesthesia in High‐Risk Patients—A Randomised Clinical Feasibility Trial
Authors' conclusion
While not all feasibility goals were achieved, separation in blood pressure and adherence to targets were adequate.
Study context
- Population
- ASA 3–5 patients scheduled for major surgery under GA, 8 hospitals in Denmarkof 1690 eligible
- Participants
- 483 participants
- Comparison
- Minimum MAP target of 60, 70 or 80 mmHg, or 90% of baseline SBP, during GA
- Primary endpoint
- Feasibility
Methodological detailsmulticentre, factorial, feasibility
- Multicentre
- Factorial
- Feasibility
Primary result
As reported in the abstract
Randomised of eligible patients, below the goal of 50%
483
29%
Secondary outcomes
| Outcome | Median difference (days) (95% CI) | |
|---|---|---|
| DAOH · 30 daysMAP-80-mmHg vs MAP-60-mmHg | −1.88 (−3.50 to −0.26) | |
| −4−202Difference, days (linear scale) |
Postoperative outcomes
- No difference in most postoperative outcomes
Safety
| Outcome | OR (95% CI) | |
|---|---|---|
| AKIMAP-80-mmHg vs MAP-60-mmHg | 4.74 (1.17–31.8) | |
| Cardiac arrhythmiasMAP-80-mmHg vs MAP-60-mmHg | 8.13 (1.35–156) | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Blood Pressure Targets During General Anaesthesia in High‐Risk Patients—A Randomised Clinical Feasibility Trial. Acta Anaesthesiol Scand. Published 11 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →