Cardiac arrest & resuscitation
Post-cardiac arrest brain injury model: neurobiomarker kinetics following global cerebral hypoperfusion-reperfusion
Authors' conclusion
Controlled (very) low-flow episodes during TAVI induce measurable, but clinically silent, elevations of NSE and S100.
Study context
- Population
- Adults undergoing transcatheter aortic valve implantation (TAVI) with rapid ventricular pacing (RVP, 120–200 bpm) as a model of brief cardiac arrest
- Participants
- 76 adults
- Outcome
- Serum neurobiomarker kinetics after RVP
Methodological detailssingle-centre, self-controlled
- Single-centre
- Self-controlled
Main finding
As reported in the abstract
- Neuron specific enolase (NSE), pre-procedure (T0), median [IQR] µg/L
- 10.6 [9.1-13.0]
- NSE, 20 min (T20), median [IQR] µg/L
- 12.8 [11.6-15.5]
- NSE, 65 min (T65), median [IQR] µg/L
- 15.1 [13.0-18.6]
- NSE, 110 min (T110), median [IQR] µg/L
- 15.8 [13.8-18.6]
- NSE, 200 min (T200), median [IQR] µg/L
- 17.0 [14.2-20.5]
- S100B, pre-procedure (T0), median [IQR] µg/L
- 0.05 [0.04-0.07]
- S100B, 20 min (T20), median [IQR] µg/L
- 0.13 [0.10-0.18]
- S100B, 65 min (T65), median [IQR] µg/L
- 0.14 [0.11-0.23]
- S100B, 110 min (T110), median [IQR] µg/L
- 0.11 [0.08-0.16]
- S100B, 200 min (T200), median [IQR] µg/L
- 0.08 [0.06-0.12]
Observational data: associations, not effects.
Further findings
Cumulative RVP duration and cerebral flow
- Median cumulative RVP duration, s (IQR 41-92)
- 60
- During RVP, middle cerebral artery (MCA) and common carotid (CCA) flow showed a very low-flow state; aortic pressure fell below presumed autoregulatory threshold
Safety
- Patients developing neurological deficits
- 0
Original publication
Post-cardiac arrest brain injury model: neurobiomarker kinetics following global cerebral hypoperfusion-reperfusion. Resuscitation. Published 17 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →