Pediatric anesthesia & critical care

Postanesthesia Apnea in Former Preterm and Term Infants: A Qualitative Systematic Review and Meta-analysis

AnesthesiologyPublished Systematic review and meta-analysis

Authors' conclusion

Postmenstrual age appears to be the strongest and most consistent risk factor for postanesthesia apnea; neuraxial anesthesia may reduce this risk.

Study context

Population
Former preterm and term infants undergoing anesthesia115 articles
Outcome
Major risk factors for postanesthesia apnea
Methodological detailsmeta-regression, PRISMA
  • Meta-regression
  • PRISMA

Pooled result

As reported in the abstract

Postanesthesia apnea

Median incidence of apnea across studies (range, 0 to 85%)

7.6%

Publication year, multivariable best fitting model (64 articles), OR, CI 0.91 to 0.964, P < 0.001

0.936

Postmenstrual age, multivariable best fitting model (64 articles), OR, CI 0.828 to 0.954, P = 0.001

0.889

Further pooled results

OutcomeOR (CI)P value
Apnea, neuraxial vs GAMeta-regression0.236 (0.094–0.592)P = 0.003

Recommended postanesthesia monitoring duration

Ranged by postmenstrual age
6 to 24 h

Original publication

Postanesthesia Apnea in Former Preterm and Term Infants: A Qualitative Systematic Review and Meta-analysis. Anesthesiology. Published 17 February 2026. doi:10.1097/aln.0000000000006014

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