Pediatric anesthesia & critical care
Effect of positive end expiratory pressure on non‐hypoxic apnea time and atelectasis during induction of anesthesia in infant: A randomized controlled trial
Authors' conclusion
The application of positive end-expiratory pressure reduced the incidence of atelectasis and extended the non-hypoxic apnea time in infants who are 6 months old or younger. However, it did not affect the incidence of atelectasis nor the non-hypoxic apnea time in patients aged older than 6 months.
Study context
- Population
- Infants under 1 year of age undergoing anesthesia induction with FiO2 0.8included in final analysis
- Participants
- 84 participants
- Comparison
- Face-mask ventilation with 7 cmH2O positive-end-expiratory pressure (PEEP) vs zero end-expiratory pressure during induction (FiO2 0.8)
- Primary endpoint
- Non-hypoxic apnea time (cessation of ventilation to SpO2 95%)
Methodological detailsage stratified
- Age stratified
Primary result
Non-hypoxic apnea time, infants ≤6 months
Mean difference
−9.4
95% CI −16.0 to −2.9
P = 0.005
By group
Positive end-expiratory pressure vs Zero end-expiratory pressure
mean difference −9.4 (95% CI −16.0 to −2.9); P = 0.005
As reported in the abstract
Secondary outcomes
| Outcome | Positive end-expiratory pressure | Zero end-expiratory pressure | Mean difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Atelectasis score (ultrasonography), infants ≤6 months | 17.0 | 31.5 | 11.6 (7.5–15.6) | P < 0.001 | |
| −1001020Difference (linear scale) |
Atelectasis score (ultrasonography), infants ≤6 months
- Not decreased in infants aged older than 6 months
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of positive end expiratory pressure on non‐hypoxic apnea time and atelectasis during induction of anesthesia in infant: A randomized controlled trial. Paediatr Anaesth. Published 9 July 2024. doi:10.
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