Perioperative medicine & outcomes
Postoperative Delirium and Neurocognitive Disorders Associated With Inflammatory and Neuronal Injury Biomarkers: A Prospective, Longitudinal, Cohort Study
Authors' conclusion
Using updated nomenclature, postoperative delirium and postoperative NCD affect a third of surgical patients and inflammatory and neuronal injury markers are elevated after surgical intervention.
Study context
- Population
- Older adults aged ≥60 years undergoing major elective noncardiac surgery
- Participants
- 79 adults
- Outcome
- Incidence of postoperative delirium and NCD; biomarker changes
Main finding
As reported in the abstract
- Postoperative delirium
- Thirteen patients (15.2%)
- Postoperative neurocognitive disorders (NCD) at 3 months
- 18 of 63 (28.6%)
- NCD at long-term follow-up
- 17 of 46 (37.0%)
- IL-6 at 48 h vs baseline (times higher)
- 10.3
- IL-10 at 48 h vs baseline (times higher)
- 1.9
- Total Tau at 48 h vs baseline (times higher)
- 1.3
- p-Tau181 at 48 h vs baseline (times higher)
- 1.2
- NfL at 48 h vs baseline (times higher)
- 1.6
- IL-18 levels (times lower)
- 1.1
Observational data: associations, not effects.
Further findings
Greater IL-6 elevation and delirium risk (linear mixed-effects model)
- β
- 22.23
- SE
- 9.48
- P
- P = 0.02
Greater IL-6 elevation and long-term NCD (linear mixed-effects model)
- β
- 12.46
- SE
- 6.02
- P
- P = 0.04
Original publication
Postoperative Delirium and Neurocognitive Disorders Associated With Inflammatory and Neuronal Injury Biomarkers: A Prospective, Longitudinal, Cohort Study. Anesth Analg. Published 16 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →