Perioperative medicine & outcomes
Preoperative Biofluid Biomarkers for Predicting Postoperative Neurocognitive Disorders in Older Adults: A Systematic Review
Authors' conclusion
In conclusion, preoperative biofluid amyloid biomarkers may hold potential utility for the prediction of POCD, although current evidence remains limited.
Study context
- Population
- Older surgical participants aged ≥60 years (excluding intracranial surgery)
- Participants
- 2,103 participants · 15 studies
- Outcome
- Association of preoperative biofluid biomarkers with cognitive decline (PND/POCD) beyond 7 days
- Follow-up
- Beyond 7 days
Methodological detailspooled incidence of postoperative cognitive dysfunction (POCD), 6 databases and 3 trial registries searched to 17 January 2024, Biomarkers: blood (9 studies), cerebrospinal fluid (CSF) (4), both (2); neuronal injury (9), inflammation (5), amyloid (5), Tau (1)
- Pooled incidence of POCD
- 6 databases and 3 trial registries searched to 17 January 2024
- Biomarkers: blood (9 studies), CSF (4), both (2); neuronal injury (9), inflammation (5), amyloid (5), Tau (1)
Pooled result
As reported in the abstract
Association of preoperative biomarkers with POCD
Amyloid biomarkers most promising: studies demonstrating associations of lower preoperative biofluid amyloid levels with increased risk of POCD
4 of 5
Further pooled results
Pooled incidence of POCD (binary cognitive outcome, 9 studies) · <3 months
- Incidence of POCD at <3 months
- 23.4% (95% CI 6.6-46.2)
Pooled incidence of POCD (binary cognitive outcome, 9 studies) · 3 to <12 months
- Incidence of POCD at 3 to <12 months
- 11.4% (95% CI 8.1-15.0)
Pooled incidence of POCD (binary cognitive outcome, 9 studies) · ≥12 months
- Incidence of POCD at ≥12 months
- 6.9% (95% CI 1.9-14.5)
Original publication
Preoperative Biofluid Biomarkers for Predicting Postoperative Neurocognitive Disorders in Older Adults: A Systematic Review. Anesth Analg. Published 21 November 2024. doi:10.
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