Perioperative medicine & outcomes
Postoperative haemoglobin and anaemia-associated ischaemic events after major noncardiac surgery: A sex-stratified cohort study
Authors' conclusion
Postoperative haemoglobin levels following major noncardiac surgery were nonlinearly associated with ischaemic complications or mortality, without any clinically important interaction with patient sex.
Study context
- Population
- Men and women undergoing elective major noncardiac surgery, large university hospital health system in China
- Participants
- 26,049 men
- Exposure
- Postoperative nadir haemoglobin, by sex
- Menn = 15,757
- Womenn = 10,292
- Outcome
- Composite outcome per 10 g l-1 decrease in postoperative nadir haemoglobin
Methodological detailsprospective validation, sex-stratified
- Prospective validation
- Sex-stratified
Main finding
As reported in the abstract
Adjusted odds ratio (95% CI)
Menbelow 130 g l-1
1.43(1.37–1.50)
Womenbelow 120 g l-1
1.45(1.35–1.55)
Per 10 g l-1 decrease in postoperative nadir, as printed
- No significant interaction between sex and the haemoglobin–outcome association
- P for interaction = 0.673
Observational data: associations, not effects.
Further findings
- Validation in an external prospective cohort (n = 2120) with systematic troponin and creatinine measurement confirmed the findings
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Postoperative haemoglobin and anaemia-associated ischaemic events after major noncardiac surgery: A sex-stratified cohort study. J Clin Anesth. Published 11 March 2024. doi:10.
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