Perioperative medicine & outcomes
Sex-Specific Associations Between Preoperative Hemoglobin and Outcomes After Major Noncardiac Surgery: A Retrospective Cohort Study
Authors' conclusion
Low preoperative hemoglobin was associated with a higher risk of complications or mortality after elective noncardiac surgery in both men and women. No differences in the strength of associations between sexes were found.
Study context
- Population
- Adults undergoing elective major noncardiac surgery in a large academic hospital
- Participants
- 22,550 adults
- Exposure
- Preoperative hemoglobin, women vs men
- Womenn = 9,268
- Menn = 13,282
- Outcome
- Composite of:
- Postoperative mortality or cardiovascular
- Renal
- Pulmonary
- Infectious complications
- Follow-up
- During hospitalization
Methodological detailssingle-centre, multivariable-adjusted, sex-stratified
- Single-centre
- Multivariable-adjusted
- Sex-stratified
Main finding
As reported in the abstract
Primary composite outcome
Odds ratio per 1 g/dL increase in hemoglobin (95% CI)P value
Women
0.93(0.87–0.98)
P = 0.013Men
0.94(0.90–0.97)
P < 0.001Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Sex-Specific Associations Between Preoperative Hemoglobin and Outcomes After Major Noncardiac Surgery: A Retrospective Cohort Study. Anesth Analg. Published 20 October 2023. doi:10. 1213/ ane. 0000000000006661
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