Hemodynamics, fluids & transfusion
Practical Anemia Bundle and Hemoglobin Recovery in Critical Illness: A Randomized Clinical Trial
Primary result · Hemoglobin concentrationResult — go to the resultAdjusted mean difference 0.69 g/dL 95% CI 0.13–1.20Authors' conclusion
This randomized clinical trial found that a multifaceted anemia prevention and treatment bundle was feasible, was well tolerated, and improved posthospitalization hemoglobin concentrations up to 3 months in critically ill adults.
Study context
- Population
- Critically ill adults (≥18 years) with moderate to severe anemia (hemoglobin <10 g/dL) in postsurgical and medical ICUs at a large US medical center
- Participants
- 100 adults
- Comparison
- Multifaceted anemia management bundle vs standard care
- Interventionn = 49
- Standard caren = 51reference
- Primary endpoint
- Mean difference in hemoglobin concentration
- Follow-up
- 1 month after hospital discharge
Methodological detailsparallel group, single-centre
- Parallel group
- Single-centre
Primary result
Hemoglobin concentration · 1 month after discharge
Adjusted mean difference
0.69 g/dL
95% CI 0.13–1.20
P = 0.02
By group
Intervention vs Standard care
adjusted mean difference 0.69 g/dL (95% CI 0.13–1.20); P = 0.02
As reported in the abstract
Original publication
Practical Anemia Bundle and Hemoglobin Recovery in Critical Illness: A Randomized Clinical Trial. JAMA Netw Open. Published 3 March 2025. doi:10.
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