Perioperative medicine & outcomes
Association Between Preoperative Anemia and Cognitive Function in a Large Cohort Study of Older Patients Undergoing Elective Surgery
Main finding · Hgb level vs clock drawing time (CDT)Result — go to the resultSpearman correlation coefficient −.15 95% CI −.17 to −.13Authors' conclusion
We found that anemia, cognitive vulnerability, and chronic health disease states predicted death within 1 year of surgery, and that these preoperative factors negatively contribute to surgical outcomes such as time in the ICU, length of hospital stay, nonhome discharge, and 1-year mortality.
Study context
- Population
- Patients aged ≥65 years undergoing elective surgery with anaesthesia, with preoperative hemoglobin (Hgb) and preoperative cognitive screening, University of Florida Health Shandsof 14,795 assessed
- Participants
- 8,643 patients
- Exposure
- Preoperative anaemia vs no anaemia
- Outcome
- Discharge disposition and 1-year mortality
- Follow-up
- 1 year
Methodological detailssingle-centre perioperative database
- Single-centre perioperative database
Main finding
Hgb level vs clock drawing time (CDT)
Spearman correlation coefficient
−.15
95% CI −.17 to −.13
P < 0.0001
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (95% CI) | |
|---|---|---|
| Death within 1 year of surgeryMild anemic vs Not anemic · adjusted for ASA, Fried Frailty, and covariates | 2.7 (2.1–3.5) | |
| Death within 1 year of surgeryModerate/severe anemic vs Not anemic · adjusted for ASA, Fried Frailty, and covariates | 3.6 (2.7–4.9) | |
| 0.20.5125Odds ratio (log scale) |
Prevalence of anemia
- Anemic
- 26.7%
- Mild anemia
- 16.8%
- Moderate anemia
- 9.5%
- Severe anemia
- 0.4%
Hgb vs ASA physical status, Fried Frailty Index, hospital and ICU LOS
- Hgb negatively correlated with ASA, Fried Frailty Index, hospital and ICU LOS
Nonhome discharge (multivariable model)
- Age, surgical service, ASA and Fried Frailty Index significantly predicted nonhome discharge
Death within 1 year of surgery
- Age, surgical service, ASA, Fried Frailty Index and Hgb independently predicted 1-year death
Original publication
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