Perioperative medicine & outcomes
Preoperative cognitive function and surgical outcomes under general anesthesia among older patients
Authors' conclusion
Older patients with preoperative cognitive impairment undergoing general anesthesia have higher mortality and morbidity rates, particularly in patients with KDSQ-C scores ≥11.
Study context
- Population
- Older patients (screened from age 66 y) undergoing surgery under GA in South Korea, 2021
- Participants
- 108,158 patients
- Exposure
- Preoperative Korean Dementia Screening Questionnaire-Cognition (KDSQ-C) ≥ 6 vs 0-5
- Outcome
- Mortality
- Follow-up
- 90 days
Methodological detailsnationwide database, multivariable Cox regression
- Nationwide database
- Multivariable Cox regression
Main finding
As reported in the abstract
90-day mortality
Each group vs KDSQ-C 0-5Hazard ratio (95 % CI)P value
KDSQ-C ≥ 635 % higher risk
1.35(1.15–1.57)
P < 0.001KDSQ-C 11-15
1.54(1.13–2.11)
P = 0.007KDSQ-C 16-20
1.98(1.31–2.99)
P = 0.001KDSQ-C 21-25
1.99(1.29–2.57)
P = 0.004KDSQ-C 26-30
2.03(1.26–3.28)
P = 0.004Observational data: associations, not effects.
Further findings
One-year all-cause mortality and postoperative complications
- Similar results to 90-day mortality
Original publication
Preoperative cognitive function and surgical outcomes under general anesthesia among older patients. J Clin Anesth. Published 7 May 2025. doi:10.
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