Perioperative medicine & outcomes
Cognitive impairment influences perioperative quality of life in older surgical patients: A multicenter longitudinal study
Authors' conclusion
Older patients with CIAD8 experienced persistently lower QoL throughout the perioperative period, compared to those without CIAD8. Although QoL transiently declined within the CIAD8 group at 30 days, longitudinal QoL trajectories did not differ significantly between participants with and without CIAD8.
Study context
- Population
- Patients aged ≥65 years undergoing elective non-cardiac surgery at two academic hospitals289 completed 90-day follow-up
- Participants
- 370 patients
- Exposure
- AD8-defined CI vs no AD8-defined CI
- Outcome
- QoL (0-100 visual analogue scale (VAS)) trajectories by CI status
- Follow-up
- Preoperatively, 30 and 90 days postoperatively
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
QoL (VAS 0-100)
- Longitudinal quality of life (QoL) trajectories did not differ significantly between CIAD8 and no CIAD8
- CIAD8 vs No CIAD8: P < 0.001
- CIAD8 vs No CIAD8: P < 0.001
- CIAD8 vs No CIAD8: P < 0.001
Observational data: associations, not effects.
Further findings
Preoperative QoL and postoperative outcomes
- Lower preoperative QoL associated with more all-cause complications, non-home discharge and composite adverse outcomes within 30 days, and composite adverse outcomes at 90 days
Independent factors for perioperative QoL
- Higher pain, frailty, anxiety/depression and CIAD8 independently associated with lower perioperative QoL
Original publication
Cognitive impairment influences perioperative quality of life in older surgical patients: A multicenter longitudinal study. J Clin Anesth. Published 5 September 2026. doi:10.
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