Hemodynamics, fluids & transfusion
Longitudinal changes in haemoglobin, iron stores, and inflammatory markers following surgery and in critical illness: an analysis from the Practical Anaemia Bundle for Sustained Blood Recovery randomised clinical trial
Authors' conclusion
Intravenous iron increases haemoglobin and ferritin concentrations through 3 months following critical illness.
Study context
- Population
- Critically ill adults with haemoglobin <10 g dl-1
- Participants
- 100 adults
- Comparison
- i.v. iron vs standard care
- Interventionn = 49
- Standard caren = 51reference
- Primary endpoint
- Longitudinal haemoglobin, iron assays, erythropoietin and inflammatory markers (between-group differences)
- Follow-up
- 1 and 3 months post-hospitalisation
Methodological detailsplanned analysis
- Planned analysis
Primary result
As reported in the abstract
Intervention vs Standard careAdjusted mean difference, g dl-1 (95% CI)P value
Haemoglobin at 1 month
0.69(0.13–1.25)
P = 0.015Intervention vs Standard careMultiple increase, ng/ml (95% CI)P value
Ferritin at 1 month
2.7(1.9–3.9)
P < 0.001Further findings
Correlations between laboratory values
- Ferritin and transferrin saturation, but not soluble transferrin receptor, correlated with inflammatory markers
- Inflammatory markers correlated positively with erythropoietin and negatively with haemoglobin
Haemoglobin response to i.v. iron by baseline parameters (interaction analyses)
- Soluble transferrin receptor-log ferritin index ≥1.5 identified patients likely to have greatest haemoglobin response
Original publication
Longitudinal changes in haemoglobin, iron stores, and inflammatory markers following surgery and in critical illness: an analysis from the Practical Anaemia Bundle for Sustained Blood Recovery randomised clinical trial. Br J Anaesth. Published 8 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →