Perioperative medicine & outcomes
Postoperative lymphopaenia as a risk factor for postoperative infections in cancer surgery: A prospective multicentre cohort study (the EVALYMPH study)
Authors' conclusion
POD1 lymphopaenia was associated with PIs in patients undergoing thoracic or gastrointestinal cancer surgery.
Study context
- Population
- Adults undergoing thoracic or gastrointestinal cancer surgery, 25 French centres, January 2016 to September 2017
- Participants
- 1,207 adults
- Exposure
- POD1 lymphopaenia vs no lymphopaenia as risk factor for postoperative infections
- Outcome
- Postoperative infections (urinary tract infections, pneumonia, surgical site infections, other infections: bloodstream infections or pleurisy)
- Follow-up
- 30 days after surgery
Methodological detailsmulticentre, 30-day follow-up, multivariate analysis
- Multicentre
- 30-day follow-up
- Multivariate analysis
Main finding
As reported in the abstract
Postoperative infections · 30 days
Hazard ratio (95% CI)
Lymphopaenia on POD1
1.56(1.08–2.25)
ASA score IV
4.27(1.87–9.72)
Surgery > 200 min
1.58(1.15–2.17)
- Patients with at least one infection within 30 days
- 273 (22.6%)
- Median [IQR] time to onset, days
- 8 [5 to 11]
Observational data: associations, not effects.
Further findings
Association of PI risk with lymphocyte counts
- Associated with changes in postoperative LC over time
- P = 0.001
- Not associated with preoperative LC
- P = 0.536
Risk factors for POD1 lymphopaenia
- Related to patient characteristics and duration of surgery but not to potentially modifiable other surgical or anaesthetic factors
Original publication
Postoperative lymphopaenia as a risk factor for postoperative infections in cancer surgery: A prospective multicentre cohort study (the EVALYMPH study). Eur J Anaesthesiol. Published 29 October 2024. doi:10.
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