Perioperative medicine & outcomes
Postoperative Pulmonary Complications in the ENIGMA II Trial: A Post Hoc Analysis
Primary result · AtelectasisResult — go to the resultOdds ratio 0.77 95% CI 0.62–0.97Authors' conclusion
In contrast to the earlier ENIGMA trial, nitrous oxide anesthesia in the ENIGMA II trial was associated with a lower incidence of lung atelectasis, but not pneumonia, after major surgery.
Study context
- Population
- Major surgery patients recruited to the Australian cohort of ENIGMA IIrandomized patients included
- Participants
- 2,328 patients
- Comparison
- Nitrous oxide vs nitrous oxide-free anaesthesia at FiO2 0.3
- Nitrous oxiden = 1,169
- Nitrous oxide-freen = 1,159reference
- Primary endpoint
- Atelectasis (lung atelectasis or collapse on chest radiology)
Methodological detailsoutcome assessment blinded to allocation, intention-to-treat, multicentre (10 Australian hospitals)
- Outcome assessment blinded to allocation
- Intention-to-treat
- Multicentre (10 Australian hospitals)
Primary result
Atelectasis
Odds ratio
0.77
95% CI 0.62–0.97
P = 0.023
Events by treatment group
Nitrous oxide vs Nitrous oxide-free
OR 0.77 (95% CI 0.62–0.97); P = 0.023
As reported in the abstract
Secondary outcomes
Pneumonia (diagnostic chest radiology report with fever, leukocytosis, or positive sputum culture)
- No difference in pneumonia incidence
- Intention to treat
Combined pulmonary complications
- No difference in combined pulmonary complications
- Intention to treat
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Postoperative Pulmonary Complications in the ENIGMA II Trial: A Post Hoc Analysis. Anesthesiology. Published 16 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →