Perioperative medicine & outcomes
Postoperative recovery after breast cancer surgery: A randomised controlled trial of opioid-based versus opioid-free anaesthesia with thoracic paravertebral block
Authors' conclusion
TPVB-based opioid-free anaesthesia improved early postoperative quality of recovery without compromising pain control in patients undergoing breast cancer surgery.
Study context
- Population
- Adult women undergoing breast cancer surgery, without remote metastasis, chronic pain or chronic opioid use
- Participants
- 80 women
- Comparison
- Thoracic paravertebral block (TPVB)-based opioid-free anaesthesia vs opioid-based anaesthesia
- Primary endpoint
- Quality of Recovery (QoR-15) global score
- Follow-up
- 24 h after surgery
Methodological details1 : 1 randomisation, single-centre tertiary teaching hospital
- 1 : 1 randomisation
- Single-centre tertiary teaching hospital
Primary result
As reported in the abstract
OFA
140.3
± 5.2
Control
132.0
± 12.0
P < 0.001
Secondary outcomes
Good recovery (QoR-15 global score ≥118)
P = 0.012
| Outcome | OFA | Control | P value |
|---|---|---|---|
| QoR-15 physical comfort domain | 45.7 ± 3.0 | 41.8 ± 5.7 | P < 0.001 |
| QoR-15 physical independence domain | 18.3 ± 2.2 | 16.3 ± 4.5 | P = 0.014 |
QoR categories (sensitivity analysis)
- Improved QoR in the OFA group also evident in sensitivity analysis
Pain outcomes and health-related quality of life
- The two groups did not differ
Original publication
Postoperative recovery after breast cancer surgery: A randomised controlled trial of opioid-based versus opioid-free anaesthesia with thoracic paravertebral block. Eur J Anaesthesiol. Published 23 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →