Perioperative medicine & outcomes
Postoperative systemic inflammation after major abdominal surgery: patient‐centred outcomes
Main finding · Persistent disability or death up to 90 daysResult — go to the resultAdjusted relative risk 1.76 95% CI 1.31–2.36Authors' conclusion
Marked postoperative systemic inflammation was associated with increased risk of complications, poor quality of recovery and persistent disability or death up to 90 days after surgery.
Study context
- Population
- High-risk, elective, major abdominal surgery patients in the RELIEF trial, 47 centres in seven countries, May 2013 to September 2016
- Participants
- 3,000 participants · 47 centres
- Exposure
- Quartile 4 vs Quartile 1
- Outcome
- Co-primary: persistent disability or death up to 90 days; quality of recovery (QoR-15) at days 3 and 30
- Follow-up
- 90 days; days 3 and 30
Methodological detailsanalysis of prospectively collected RELIEF trial data, multicentre, multiple imputation
- Analysis of prospectively collected RELIEF trial data
- Multicentre
- Multiple imputation
Main finding
Persistent disability or death up to 90 days · up to 90 days
Adjusted relative risk
1.76
95% CI 1.31–2.36
P < 0.001
Quartile 4 vs Quartile 1
adjusted RR 1.76 (95% CI 1.31–2.36); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Difference (95% CI) | P value | |
|---|---|---|---|
| Quality of recovery (QoR-15), risk-adjusted estimated medians (co-primary) · up to day 3Quartile 4 vs Quartile 1 | −14.4 (−17.38 to −10.71) | P < 0.001 | |
| Quality of recovery (QoR-15), risk-adjusted estimated medians (co-primary) · day 30Quartile 4 vs Quartile 1 | −5.94 (−8.92 to −2.95) | P < 0.001 | |
| −20−10010Difference (linear scale) |
Original publication
Postoperative systemic inflammation after major abdominal surgery: patient‐centred outcomes. Anaesthesia. Published 2 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →