Postoperative Urinary Retention After Reversal of Neuromuscular Block by Neostigmine versus Sugammadex in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Trial
Primary result · Incidence of POURResult — go to the resultDifference 12.8% 95% CI 4%–22%Authors' conclusion
In patients undergoing laparoscopic cholecystectomy, neuromuscular blockade with rocuronium followed by reversal with sugammadex provides a significant reduction in postoperative urinary retention when compared to reversal with neostigmine, without any major adverse effects.
Study context
- Population
- Patients undergoing laparoscopic cholecystectomyenrolled
- Participants
- 235 patients
- Comparison
- Sugammadex vs neostigmine for reversal of rocuronium-induced NMB
- Primary endpoint
- Incidence of postoperative urinary retention (POUR)
Primary result
As reported in the abstract
Difference
12.8%
95% CI 4%–22%
P < 0.001
Sugammadex vs Neostigmine
difference 12.8% (95% CI 4%–22%); P < 0.001
Safety
- No major adverse events in either group
Original publication
Postoperative Urinary Retention After Reversal of Neuromuscular Block by Neostigmine versus Sugammadex in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Trial. Anesth Analg. Published 6 March 2026. doi:10.
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