Potential of acetaminophen on the sublingual microcirculation and peripheral tissue perfusion of febrile septic patients: prospective observational study
Authors' conclusion
ACT infusion did not show a clear correlation with cell-free Hb; however, it exhibited protective effect toward the microcirculation that was evident in particular in septic patients.
Study context
- Population
- Adult febrile septic and septic shock patients treated with acetaminophen (ACT) for pyrexia
- Participants
- 50 participants
- Exposure
- Sublingual microcirculation and peripheral tissue perfusion before vs after acetaminophen (ACT) for pyrexia
- Outcome
- Sublingual microcirculation and peripheral tissue perfusion (Near Infrared Spectroscopy (NIRS) with vascular occlusion test) before and after ACT
Methodological detailsbefore-and-after
- Before-and-after
Main finding
As reported in the abstract
Sublingual microcirculation and peripheral tissue perfusion
- Significant increase in density of perfused small and total sublingual vessels 30 min after ACT
- Increase in Microvascular Flow Index (MFI) and decrease in flow heterogeneity
- Faster reperfusion curve after vascular occlusion test at t1 (higher microvascular reactivity)
Observational data: associations, not effects.
Further findings
- No clear correlation of ACT infusion with cell-free hemoglobin (Hb)
Original publication
Potential of acetaminophen on the sublingual microcirculation and peripheral tissue perfusion of febrile septic patients: prospective observational study. Ann Intensive Care. Published 10 February 2024. doi:10.
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