Pre-Referral Antibiotics and Mortality Among Adults With Sepsis in Southeast Asia: A Secondary Analysis of a Prospective Cohort Study
Authors' conclusion
In rural Thailand, antibiotic administration prior to referral was associated with lower hazard of death in patients with septic shock.
Study context
- Population
- Adults with sepsis (primary diagnosis of infection, modified SOFA ≥2) referred from community hospitals to a tertiary care hospital in northeastern Thailand, 2013–2017adults referred from community hospitals
- Participants
- 2,593 adults
- Comparison
- Pre-referral antibiotics vs no pre-referral antibiotics
- Pre-referral antibioticsn = 1,897
Methodological detailspropensity score-matched, single-centre
- Propensity score-matched
- Single-centre
Primary result
As reported in the abstract
Hazard of death by shock status (subgroup) · 28 days
Pre-referral antibiotics vs No pre-referral antibioticsHazard ratio (95% CI)
Septic shock (n = 244)
0.38(0.19–0.75)
Sepsis without shock (n = 722)
1.36(0.96–1.92)
Further findings
28-day mortality, whole cohort
- Twenty-eight-day mortality
- 18.9%
Bacteraemia (blood cultures grew bacteria)
- Blood cultures grew bacteria
- 313 (12.1%)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Pre-Referral Antibiotics and Mortality Among Adults With Sepsis in Southeast Asia: A Secondary Analysis of a Prospective Cohort Study. Crit Care Med. Published 6 November 2025. doi:10.
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