Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England
Authors' conclusion
Minimally invasive surgical approaches were associated with lower odds of persistent opioid use and may represent a modifiable risk factor.
Study context
- Population
- Adults undergoing colectomy in England, 2010 to 2019 (Clinical Practice Research Datalink and Hospital Episode Statistics)
- Participants
- 93,262 adults
- Exposure
- Pre-admission opioid exposure: currently exposed or previously exposed vs opioid-naïve
- Outcome
- Persistent postoperative opioid use (opioid prescription within 90 days of discharge plus ≥1 opioid prescription 91-180 days after discharge)
Methodological detailspopulation-based, linked primary and secondary care data
- Population-based
- Linked primary and secondary care data
Main finding
As reported in the abstract
Persistent postoperative opioid use
- Persistent postoperative opioid use, whole cohort
- 7540 (8.1%)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Persistent opioid use: long-acting vs short-acting opioid formulations in the 180 days before colectomyMultivariable logistic regression | 3.41 (3.07–3.77) | |
| 0.20.5125Odds ratio (log scale) |
Opioid prescription within 90 days of discharge
- At least one opioid prescription, whole cohort
- 15,081 (16.2%)
- Of these, opioid-naïve
- 6791 (45.0%)
- Of these, currently exposed
- 7528 (49.9%)
- Of these, previously exposed
- 762 (5.0%)
Predictors of persistent opioid use
- Previous opioid exposure, high deprivation index, multiple comorbidities, long-acting opioids, white race and open surgery
- Minimally invasive surgical approaches associated with lower odds
Original publication
Predictors of persistent postoperative opioid use following colectomy: a population‐based cohort study from England. Anaesthesia. Published 2 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →