Perioperative medicine & outcomes

Prehabilitation for Patients Undergoing Orthopedic Surgery: A Systematic Review and Meta-analysis

JAMA Netw OpenPublished Systematic review and meta-analysis of randomised trials

Authors' conclusion

In this systematic review and meta-analysis of RCTs, moderate-certainty evidence supported prehabilitation over usual care in improving preoperative function and strength in TKR and HRQOL and muscle strength in THR, high-certainty evidence in reducing back pain, and moderate-certainty evidence in improving HRQOL in lumbar surgery. Postoperatively, moderate-certainty evidence supported prehabilitation for function following TKR at 6 weeks and lumbar surgery at 6 months.

Study context

Population
Patients undergoing orthopedic surgery
Participants
3,570 patients · 48 randomized clinical trials (RCTs)
Comparison
Prehabilitation vs usual care
Outcome
Pain, function, muscle strength, and health-related quality of life (HRQOL)
Methodological detailsrandom-effects model, GRADE, PRISMA
  • Random-effects model
  • GRADE
  • PRISMA

Pooled result

As reported in the abstract

Preoperative outcomes (pain, function, muscle strength, HRQOL) by surgery type · Preoperatively
Prehabilitation vs Usual careEstimate (95% CI)
TKR, function; moderate-certainty evidence
SMD −0.70(−1.08 to −0.32)
TKR, muscle strength and flexion; moderate-certainty evidence
SMD 1.00(0.23–1.77)
THR, HRQOL (36-item Short Form Health Survey); moderate-certainty evidence
WMD 7.35(3.15–11.54)
THR, muscle strength and abduction; moderate-certainty evidence
SMD 1.03(0.03–2.02)

Further pooled results

OutcomeSMD (95% CI)
Postoperative function, TKR · 6 weeksModerate certainty−0.51 (−0.85 to −0.17)
Postoperative function, lumbar surgery · 6 monthsModerate certainty−2.35 (−3.92 to −0.79)

Other outcomes

Other differences favoring prehabilitation of low to very low quality of evidence

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

Prehabilitation for Patients Undergoing Orthopedic Surgery: A Systematic Review and Meta-analysis. JAMA Netw Open. Published 3 April 2023. doi:10.1001/jamanetworkopen.2023.8050

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