Cardiac arrest & resuscitation
Prehospital antiplatelet therapy in patients with out-of-hospital cardiac arrest suspected of acute coronary syndrome
Authors' conclusion
Prehospital antiplatelet therapy was safe, but showed no apparent improvement in survival or cardiovascular outcomes in patients with OHCA suspected of ACS.
Study context
- Population
- Patients with out-of-hospital cardiac arrest (OHCA) suspected of ACS referred for coronary angiography within 24 h, 2012 to 2024
- Participants
- 411 patients
- Exposure
- Prehospital antiplatelet therapy vs no prehospital antiplatelet therapy
- Prehospital antiplatelet therapyn = 217
- Outcome
- All-cause death
- Follow-up
- 30 days
Methodological detailsinverse probability weighting, consecutive patients
- Inverse probability weighting
- Consecutive patients
Main finding
As reported in the abstract
P = 0.280
Observational data: associations, not effects.
Further findings
In-hospital major adverse cardiovascular events (MACE)
- Not significantly different between the two strategies
30-day all-cause death in subgroups with ST-segment elevation or successfully resuscitated (subgroup)
- Results appear consistent in subgroups
Safety
In-hospital major bleeding (BARC ≥ 3)
- Not significantly different between the two strategies
Original publication
Prehospital antiplatelet therapy in patients with out-of-hospital cardiac arrest suspected of acute coronary syndrome. Resuscitation. Published 28 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →