Perioperative medicine & outcomes
Preoperative cognitive training for the prevention of postoperative delirium and cognitive dysfunction: a systematic review and meta-analysis
Authors' conclusion
Current evidence is insufficient to determine the beneficial effect of preoperative cognitive training on POD or POCD.
Study context
- Population
- Patients undergoing elective surgery (mean or median age 66–73 years)
- Participants
- 864 patients · 7 RCTs
- Comparison
- Preoperative cognitive training vs usual care
- Outcome
- Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD)
Methodological detailsrandom-effects, post hoc trial sequential analysis, Grading of Recommendations, Assessment, Development and Evaluation (GRADE), Four trials high and three unclear risk of bias, Quality of reporting of interventions (TIDieR) fair to moderate
- Random-effects
- Post hoc trial sequential analysis
- GRADE
- Four trials high and three unclear risk of bias
- Quality of reporting of interventions (TIDieR) fair to moderate
Pooled result
As reported in the abstract
Cognitive prehabilitation vs Usual careRelative risk (95% CI)
POD; I2 = 30%; low certainty, five trials
0.82(0.57–1.18)
Early POCD; I2 = 67%; very low certainty, four trials
0.93(0.58–1.49)
Further pooled results
Participant compliance
- Compliance not reported or mostly below 70%
Original publication
Preoperative cognitive training for the prevention of postoperative delirium and cognitive dysfunction: a systematic review and meta-analysis. Perioper Med (Lond). Published 30 November 2024. doi:10.
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