Neuroanesthesia & neurocritical care
Preoperative glycated hemoglobin as a predictor of infection in patients undergoing spinal surgery: A retrospective analysis of MIMIC-IV database
Main findingResult — go to the resultOdds ratio 3.20 95 % CI 1.22–8.36Authors' conclusion
Elevated preoperative HbA1c substantially increases the likelihood of early clinician suspicion and empirical treatment of postoperative infections after spinal surgery.
Study context
- Population
- Adults undergoing spinal surgery with recorded preoperative HbA1c
- Participants
- 246 adults
- Exposure
- Elevated vs lower preoperative HbA1c
- Outcome
- Clinician-suspected postoperative infection (culture orders plus antibiotic initiation)
- Follow-up
- 24 h after surgery
Methodological detailssingle-centre, MIMIC-IV database
- Single-centre
- MIMIC-IV database
Main finding
As reported in the abstract
Odds ratio
3.20
95 % CI 1.22–8.36
P = 0.018
HbA1c ≥6.5 % vs HbA1c <6.5 %
OR 3.20 (95 % CI 1.22–8.36); P = 0.018
Observational data: associations, not effects.
Secondary outcomes
- Elevated HbA1c did not independently predict Sepsis-3 sepsis or septic shock
Original publication
Preoperative glycated hemoglobin as a predictor of infection in patients undergoing spinal surgery: A retrospective analysis of MIMIC-IV database. J Clin Anesth. Published 28 October 2025. doi:10.
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