Perioperative medicine & outcomes
Preoperative inflammatory markers for prediction of postoperative clinical outcomes: a retrospective cohort study
Authors' conclusion
Elevated inflammatory indices were significantly associated with 30-day mortality and ICU stay of > 24 hr. In multivariable Analysis, they improved the prediction of 30-day mortality risk.
Study context
- Population
- Perioperative adults (≥ 21 yr) admitted to Singapore General Hospital, 2017–2020
- Participants
- 53,375 adults
- Exposure
- Elevated vs non-elevated preoperative inflammatory markers
- Outcome
- 30-day mortality and ICU stay > 24 hr
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
30-day mortality (multivariable models with a single inflammatory index) · 30 days
Odds ratio (95% CI)
RDWsingle-index model
2.69(2.10–3.44)
NLRmodel A3
2.40(1.89–3.06)
PLRmodel A4
1.91(1.50–2.43)
- Observed 30-day mortality
- 0.9% (497/53,375)
Observational data: associations, not effects.
Further findings
30-day mortality (multivariable model with all three inflammatory indices)
| OR (95% CI) | ||
|---|---|---|
| RDWAll three indices model · multivariable analysis | 2.61 (2.04–3.33) | |
| NLRAll three indices model · multivariable analysis | 2.07 (1.58–2.72) | |
| 0.20.5125Odds ratio (log scale) |
- Model had statistically significantly better area under the receiver operating curve (AUROC) than a model without any inflammatory index
Intensive care unit (ICU) admission > 24 hr
- ICU admission > 24 hr
- 2.2% (1,201/53,375)
- Elevated neutrophil:lymphocyte ratio (NLR), platelet:lymphocyte ratio (PLR) and RDW predictive of 30-day mortality and ICU stay > 24 hr on univariable analysis
Original publication
Preoperative inflammatory markers for prediction of postoperative clinical outcomes: a retrospective cohort study. Can J Anaesth. Published 22 October 2025. doi:10.
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