Perioperative medicine & outcomes
Preoperative malnutrition is a risk factor for intraoperative hypotension in high-risk surgical patients: a propensity score–matched cohort study
Main finding · Proportion of time in relative IOHResult — go to the resultCohen's d 0.54Authors' conclusion
Preoperative malnutrition is independently associated with increased intraoperative hemodynamic instability when assessed by relative blood pressure thresholds.
Study context
- Population
- Adults undergoing elective high-risk non-cardiac surgery under GA
- Participants
- 1,504 adults
- Exposure
- Malnourished vs non-malnourished patients
- Outcome
- Proportion of time in relative IOH
Methodological detailspropensity score matching, multivariable beta regression
- Propensity score matching
- Multivariable beta regression
Main finding
As reported in the abstract
Cohen's d
0.54
P < 0.001
By group
Malnourished
0.48
SD 0.16
Non-malnourished
0.39
SD 0.17
- Malnutrition independently associated with increased relative intraoperative hypotension (IOH) after covariate adjustment
- P < 0.001
Observational data: associations, not effects.
Further findings
Relative IOH duration and nadir mean arterial pressure (MAP)
- Longer IOH duration and lower nadir MAP in malnourished patients
Absolute IOH metrics (MAP < 65 mmHg)
- No significant group differences
Subgroup and sensitivity analyses
- Confirmed robustness of findings
Original publication
Preoperative malnutrition is a risk factor for intraoperative hypotension in high-risk surgical patients: a propensity score–matched cohort study. Perioper Med (Lond). Published 19 November 2025. doi:10.
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