Perioperative medicine & outcomes
Preoperative N-terminal Pro–B-type Natriuretic Peptide and High-sensitivity Cardiac Troponin T and Outcomes after Major Noncardiac Surgery: A Prospective Cohort Study
Authors' conclusion
Preoperative NT-proBNP and hs-TnT both improved the prediction for cardiovascular events after noncardiac surgery in addition to clinical evaluation, with their combination providing maximal predictive information.
Study context
- Population
- Adults with CVD or cardiovascular risk factors undergoing elective major noncardiac surgery at four hospitals in China, June 2019–September 2021
- Participants
- 2,833 adults · 4 hospitals
- Exposure
- Preoperative NT-proBNP and high-sensitivity troponin T (hs-TnT) added to clinical variables for prediction of cardiovascular events
- Outcome
- Composite of any cardiovascular events
- Follow-up
- Within 30 days after surgery
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Primary outcome incidence, n (%)
- 435 (15.4%)
- NT-proBNP, 75th vs 25th percentile, OR (95% CI) (model with clinical variables and both biomarkers)
- 1.68 (1.37 to 2.07)
- hs-TnT, 75th vs 25th percentile, OR (95% CI) (same model)
- 1.91 (1.50 to 2.43)
- Change in AUC beyond clinical predictors, NT-proBNP
- 0.028
- Change in AUC beyond clinical predictors, hs-TnT
- 0.029
- Fraction of new information, NT-proBNP
- 0.164
- Fraction of new information, hs-TnT
- 0.149
- Change in AUC, both biomarkers combined (best discrimination)
- 0.042
- Fraction of new information, both biomarkers combined
- 0.219
Observational data: associations, not effects.
Original publication
Preoperative N-terminal Pro–B-type Natriuretic Peptide and High-sensitivity Cardiac Troponin T and Outcomes after Major Noncardiac Surgery: A Prospective Cohort Study. Anesthesiology. Published 16 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →