Preoperative Platelet Count Predicts In-Hospital Mortality in Patients Supported With Venoarterial Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study
Authors' conclusion
A lower preoperative PLT count is independently associated with increased in-hospital mortality in VA-ECMO patients.
Study context
- Population
- Adults supported with venoarterial extracorporeal membrane oxygenation (VA-ECMO) at a single academic medical center, January 2015–December 2019
- Participants
- 582 adults
- Exposure
- Pre-cannulation platelet (PLT) count categories
- Outcome
- In-hospital mortality
Methodological detailssingle-centre, secondary analysis of a prospectively maintained institutional registry
- Single-centre
- Secondary analysis of a prospectively maintained institutional registry
Main finding
As reported in the abstract
Adjusted odds ratio (95% CI)P value
Each 10 × 10⁹/L increase in PLT count4% lower odds
0.96(0.94–0.98)
P = 0.0002Each 10 × 10⁹/L increase in PLT count, as printed
aOR
- G2 vs G1
- 0.51
- G3 vs G1
- 0.32
- G4 vs G1
- 0.28
Observational data: associations, not effects.
Further findings
In-hospital mortality by diabetes and preoperative anticoagulation (subgroup)
- Significant interactions with diabetes and preoperative anticoagulation; more pronounced predictive value in anticoagulated patients
- Interaction p < 0.05
Original publication
Preoperative Platelet Count Predicts In-Hospital Mortality in Patients Supported With Venoarterial Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study. J Cardiothorac Vasc Anesth. Published 9 January 2026. doi:10.
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