Preoxygenation with standard facemask combining apnoeic oxygenation using high flow nasal cannula versuss standard facemask alone in patients with and without obesity: the OPTIMASK international study
Main finding · Lowest EtO2Result — go to the resultMean difference - 2.20 CI - 3.21 to - 1.18Authors' conclusion
Combining facemask with HFNO for preoxygenation and apnoeic oxygenation was associated with increased levels of lowest EtO2 within 2 min after intubation and less desaturation.
Study context
- Population
- Adults intubated in the OR, September 2022 to December 2022intubations evaluated
- Participants
- 450 adults
- Exposure
- Facemask combined with high-flow-nasal-oxygen (HFNO) vs facemask alone
- Facemask-alonen = 233reference
- Facemask combined with HFNOn = 217
- Outcome
- Lowest end-tidal oxygen (EtO2)
- Follow-up
- Within 2 min after intubation
Methodological detailsinternational, multicentre
- International
- Multicentre
Main finding
As reported in the abstract
Mean difference
- 2.20
CI - 3.21 to - 1.18
P < 0.001
By group
Observational data: associations, not effects.
Secondary outcomes
SpO2 ≤ 95% within 2 min after intubation
P = 0.004
Denominator Facemask-alone 232 · Facemask combined with HFNO 215
| Outcome | P value |
|---|---|
| Lowest EtO2 within 2 min after intubation, patients with obesity (subgroup) | P = 0.004 |
| Lowest EtO2 within 2 min after intubation, patients without obesity (subgroup) | P = 0.001 |
Safety
- No severe adverse events recorded
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Preoxygenation with standard facemask combining apnoeic oxygenation using high flow nasal cannula versuss standard facemask alone in patients with and without obesity: the OPTIMASK international study. Ann Intensive Care. Published 4 April 2023. doi:10.
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