Preoxygenation with high-flow nasal oxygen at various flow rates in elective surgical patients: a prospective, randomised, single-blind clinical trial
Authors' conclusion
There was no difference in the safe apnoea time between preoxygenation with the three flow rates.
Study context
- Population
- Patients aged 18–84 yr, ASA physical status 1–3, scheduled for elective surgeryincluded in final analysis
- Participants
- 72 patients
- Comparison
- High-flow nasal oxygen (HFNO) preoxygenation at 70 or 95 vs 45 L min-1
- Primary endpoint
- Apnoea time until SpO2=93%
Methodological detailsprospective, single-blind, Mean duration of preoxygenation 250 s in all three groups
- Prospective
- Single-blind
- Mean duration of preoxygenation 250 s in all three groups
Primary result
As reported in the abstract
P = 0.59
Secondary outcomes
PaO2 at apnoea onset
- Higher PaO2 with 95 vs 45 L min-1; no other PaO2 differences during preoxygenation
Preoxygenation-related discomfort
- Lower discomfort with 45 L min-1 vs 70 and 95 L min-1
Original publication
Preoxygenation with high-flow nasal oxygen at various flow rates in elective surgical patients: a prospective, randomised, single-blind clinical trial. Br J Anaesth. Published 18 December 2025. doi:10.
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