Respiratory failure & ventilation
Prevalence and prognosis impact of right ventricular injury in patients with acute respiratory distress syndrome: a systematic review and meta-analysis
Authors' conclusion
RV injury is common in patients with ARDS and is consistently associated with increased mortality, irrespective of the definition used.
Study context
- Population
- Adults with acute respiratory distress syndrome (ARDS) (Berlin definition)
- Participants
- 3,977 adults · 23 studies
- Comparison
- Right ventricular (RV) injury vs no RV injury
- Outcome
- Association between RV injury and mortality
Methodological detailsrandom-effects
- Random-effects
Pooled result
As reported in the abstract
ICU mortality
RV injury vs No RV injuryEstimate (95% CI)
Unadjusted, random-effects; I2 = 56%
OR 2.49(1.81–3.42)
I2 = 42%
aOR 2.37(1.24–4.51)
I2 = 24%
aHR 2.64(1.60–4.37)
Further pooled results
Prevalence of RV injury
- Pooled prevalence
- 30% (95% CI 23-38%)
- Range across studies, depending on definition
- 6% to 56%
- COVID-19
- 33% (95% CI 22-47%)
- Non-COVID-19
- 25% (95% CI 21-29 %)
- Prevalence did not differ between COVID-19 and non-COVID-19
ICU mortality by COVID-19 status and RV injury definition (subgroup), and sensitivity analyses
- Association consistent across subgroups and sensitivity analyses excluding venovenous ECMO patients and low to moderate quality studies
Original publication
Prevalence and prognosis impact of right ventricular injury in patients with acute respiratory distress syndrome: a systematic review and meta-analysis. Ann Intensive Care. Published 16 July 2026. doi:10.
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