Perioperative medicine & outcomes
Prevalence of preoperative depression and adverse outcomes in older patients undergoing elective surgery: A systematic review and meta-analysis
Authors' conclusion
The overall prevalence of older surgical patients who suffered from depression was 23%. Preoperative depression was associated with a two-fold higher risk of postoperative delirium.
Study context
- Population
- Patients aged ≥65 years undergoing non-cardiac elective surgery
- Participants
- 2,824 patients · 13 studies
- Comparison
- Preoperative depression vs no depression
- Outcome
- Prevalence of preoperative depression
Methodological detailsPreoperative depression most assessed using GDS-15 (n = 12)
- Preoperative depression most assessed using GDS-15 (n = 12)
Pooled result
As reported in the abstract
Overall prevalence of preoperative depression
23%
95% CI 15%, 30%
Further pooled results
| Outcome | Depression | Without depression | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Postoperative deliriumI2: 0% | 32% | 23% | 2.25 (1.67–3.03) | P ≤ 0.00001 | |
| 0.20.5125Odds ratio (log scale) |
Prevalence of preoperative depression, non-cancer non-cardiac mixed surgery (subgroup)
- Pooled prevalence
- 19% (95% CI: 11%, 27%)
Prevalence of preoperative depression, orthopedic surgery (subgroup)
- Prevalence
- 17% (95% CI: 9%, 24%)
Prevalence of preoperative depression, spine surgery (subgroup)
- Prevalence
- 46% (95% CI: 28%, 64%)
Original publication
Prevalence of preoperative depression and adverse outcomes in older patients undergoing elective surgery: A systematic review and meta-analysis. J Clin Anesth. Published 26 June 2024. doi:10.
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