Primary outcomes and anticipated effect sizes in randomised clinical trials assessing peripheral and truncal nerve blocks: a systematic scoping review
Authors' conclusion
The presented outcomes and effect sizes from published trials on peripheral and truncal nerve block literature can be used in future trials to increase homogeneity in regional anaesthesia research.
Study context
- Population
- RCTs in 10 major anaesthesia journals of single-injection ultrasound-guided peripheral and truncal nerve blocks in adults undergoing surgery
- Primary endpoint
- Anticipated effect sizes for primary outcomes
Methodological detailsSearched Cochrane Library's CENTRAL, Medline, and Embase; English-language trials
- Searched Cochrane Library's CENTRAL, Medline, and Embase; English-language trials
Primary result
As reported in the abstract
Median anticipated effect sizes
0-24 h opioid consumption (median)
9 mg i.v. morphine equivalents
Pain at rest and during movement, NRS 0-10 (median)
2 points
Quality of recovery, Quality of Recovery-40 scale (median)
10 points
Quality of recovery, QoR-15 (median)
8 points
Secondary outcomes
Adequate sample size calculations reported
- Trials with continuous outcomes
- 85% (156/183)
- Trials with dichotomous outcomes
- 91% (29/32)
Statistically significant primary outcomes below anticipated effect sizes
- Trials failing to reach anticipated effect size
- 24% (24/99)
- Trials addressing this disparity in the conclusion
- 1
Original publication
Primary outcomes and anticipated effect sizes in randomised clinical trials assessing peripheral and truncal nerve blocks: a systematic scoping review. Br J Anaesth. Published 4 December 2024. doi:10.
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