Probiotic-Associated Central Venous Catheter Bloodstream Infections Lead to Increased Mortality in the ICU*
Authors' conclusion
Probiotic administration is associated with a substantial rate of probiotic-associated bloodstream infection in ICU patients with central venous catheters in place. Probiotic-associated bloodstream infections result in significantly increased mortality. Powder formulations cause bloodstream infections more frequently than nonpowder formulations.
Study context
- Population
- Adults with central venous catheters in the ICU, HCA Healthcare data warehouse
- Exposure
- Probiotics vs no probiotics
- Probioticsn = 23,015
- Outcome
- Probiotic-associated central venous catheter bloodstream infections
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
| Group | Value | NNH |
|---|---|---|
| Probiotics | 0.37% | 270 |
| No probiotics | 0 events |
Value
Probiotics0.37%
No probiotics0 events
NNH
Probiotics270
No probiotics— not stated in the abstract
Observational data: associations, not effects.
Further findings
Mortality, probiotic infection vs none
| OR (CI) | P value | ||
|---|---|---|---|
| Probiotic infection | 2.23 (1.30–3.71) | P < 0.01 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | Powder | Nonpowder | OR (CI) | P value | |
|---|---|---|---|---|---|
| Infection rate, powder vs nonpowder formulations (subgroup) | 0.76% | 0.33% | 2.03 (1.05–3.95) | P = 0.04 | |
| 0.20.5125Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Probiotic-Associated Central Venous Catheter Bloodstream Infections Lead to Increased Mortality in the ICU*. Crit Care Med. Published 1 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →