Hemodynamics, fluids & transfusion
Processed electroencephalography-guided general anesthesia and norepinephrine requirements: A randomized trial in patients having vascular surgery
Authors' conclusion
pEEG-guided - compared to non-pEEG-guided - general anesthesia reduced the amount of norepinephrine needed to keep mean arterial pressure above 65 mmHg by about a third in patients having vascular surgery.
Study context
- Population
- Patients having vascular surgery, University Medical Center Hamburg-Eppendorf, Germany96 analysed
- Participants
- 110 patients
- Comparison
- Processed electroencephalography (pEEG)-guided vs non-pEEG-guided GA
- Primary endpoint
- Average norepinephrine infusion rate from beginning of induction of anesthesia until end of surgery
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Mean difference
0.04 μg kg-1 min-1
95% CI 0.01–0.07
P = 0.004
By group
pEEG-guided vs non-pEEG-guided
mean difference 0.04 μg kg-1 min-1 (95% CI 0.01–0.07); P = 0.004
Further findings
Percentage of time Patient State Index <25
P = 0.279
Median
| Outcome | pEEG-guided | non-pEEG-guided | P value |
|---|---|---|---|
| Time-weighted MAC | 0.7 | 0.8 | P = 0.006 |
- Time-weighted MAC: pEEG-guided (0.6, 0.8); non-pEEG-guided (0.7, 0.8) as printed
- Percentage of time Patient State Index <25: pEEG-guided (1, 41); non-pEEG-guided (3, 49) as printed
Original publication
Processed electroencephalography-guided general anesthesia and norepinephrine requirements: A randomized trial in patients having vascular surgery. J Clin Anesth. Published 9 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →