Neuroanesthesia & neurocritical care
Prognosis and management of acute symptomatic seizures: a prospective, multicenter, observational study
Authors' conclusion
Even in case of structural etiology, acute symptomatic seizures bear a low risk of subsequent unprovoked seizures.
Study context
- Population
- Adults (age ≥ 18) with acute symptomatic first-ever epileptic seizure, excluding status epilepticus
- Participants
- 122 vs 19
- Exposure
- Structural vs non-structural etiology of acute symptomatic first seizure
- Structural etiologyn = 122
- Non-structural etiologyn = 19
- Outcome
- Occurrence and timing of a first unprovoked seizure relapse
- Follow-up
- 12 months
Methodological detailsmulticentre, observational
- Multicentre
- Observational
Main finding
As reported in the abstract
Cumulative unprovoked seizure relapse
Structural etiology
10.7%
11
Non-structural etiology
0
events
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Unprovoked seizure relapse: combined infectious and structural vs structural etiology aloneIndependently associated | 11.1 (1.8–69.7) | |
| 0.050.21520Odds ratio (log scale) |
Duration of antiseizure treatment
- Median duration of antiseizure treatment, months (IQR 0-9.3)
- 3.4
Relapse while on antiseizure medication
- Participants with relapse while taking antiseizure medication (of 11)
- 7
- Longer treatment durations not associated with decreased risk of relapse
Online survey of German neuro-intensivists
- Most consider ≤3 months of antiseizure medication adequate
- Non-representative online survey
Original publication
Prognosis and management of acute symptomatic seizures: a prospective, multicenter, observational study. Ann Intensive Care. Published 15 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →