ICU sedation, delirium & recovery
Prognosis of Nonagenarian ICU Patients A Bayesian analysis of prospective European studies
Authors' conclusion
Nonagenarians in the ICU have a slightly higher 30-day mortality risk compared to octogenarians, but the increase is unlikely to exceed clinically meaningful thresholds.
Study context
- Population
- Very elderly patients admitted to intensive care units (ICUs), VIP1, VIP2 and COVIP registriesVIP1, VIP2, COVIP registries
- Participants
- 8,408 patients
- Exposure
- Nonagenarians vs octogenarians
- Nonagenariansn = 807
- Octogenariansn = 7,601reference
- Outcome
- Mortality
- Follow-up
- 30 days
Methodological detailsMarkov Chain Monte Carlo simulations, non-informative, pessimistic and skeptical priors, adjusted for SOFA score, frailty and treatment limitations
- Markov Chain Monte Carlo simulations
- Non-informative, pessimistic and skeptical priors
- Adjusted for SOFA score, frailty and treatment limitations
Main finding
As reported in the abstract
30-day mortality
P = 0.12
- Probability that nonagenarians face a higher 30-day mortality risk
- 81.1-97.9%
- Probability of a clinically significant increase in mortality (RR > 1.1)
- 28.9-34.7%
- Probability of a substantial increase (RR > 1.2)
- 0.03-1.9%
Observational data: associations, not effects.
Original publication
Prognosis of Nonagenarian ICU Patients A Bayesian analysis of prospective European studies. Ann Intensive Care. Published 23 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →