Prognostic differences in sepsis caused by gram-negative bacteria and gram-positive bacteria: a systematic review and meta-analysis
Pooled result · Survival rateResult — go to the resultOR for survival 0.95 95% CI 0.70–1.28Authors' conclusion
The incidence of severe sepsis and the concentrations of inflammatory factors (CRP, PCT, TNF-α) in sepsis caused by G (-) bacteria were higher than those caused by G (+) bacteria. The two groups had no significant difference in survival rate, coagulation function, or hospital stay.
Study context
- Population
- Patients with sepsis caused by bacterial infection
- Participants
- 5,586 patients · 45 studies
- Comparison
- Sepsis caused by gram-negative vs gram-positive bacteria
- Outcome
- Survival rate
Methodological detailssensitivity analysis, meta-regression, subgroup analysis, Sensitivity analysis indicated stable results, 45 included studies: 27 high-quality, 18 moderate-quality (Newcastle-Ottawa Scale)
- Sensitivity analysis
- Meta-regression
- Subgroup analysis
- Sensitivity analysis indicated stable results
- 45 included studies: 27 high-quality, 18 moderate-quality (Newcastle-Ottawa Scale)
Pooled result
As reported in the abstract
OR for survival
0.95
95% CI 0.70–1.28
G (-) vs G (+)
OR for survival 0.95 (95% CI 0.70–1.28)
Further pooled results
| Outcome | Estimate | |
|---|---|---|
| Serum CRPG (-) vs G (+) | SMD 0.39 (95% CI 0.02–0.76) | |
| Serum procalcitoninG (-) vs G (+) | SMD 1.95 (95% CI 1.32–2.59) | |
| Serum TNF-αG (-) vs G (+) | MD 0.31 (95% CI 0.25–0.38) | |
| IL-6G (-) vs G (+) · no significant difference | SMD 1.33 (95% CI - 0.18-2.84) | |
| −2024Difference (linear scale) |
| Outcome | MD (95% CI) |
|---|---|
| WBC countG (-) vs G (+) · no significant difference | - 0.15 (- 0.96-00.66) |
Survival rate by follow-up time (subgroup)
- No significant difference
D dimer, APTT, thrombin time, INR, platelet count, LOS, ICU LOS
- No significant differences between G (-) and G (+)
Original publication
Prognostic differences in sepsis caused by gram-negative bacteria and gram-positive bacteria: a systematic review and meta-analysis. Crit Care. Published 30 November 2023. doi:10.
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